Description: An interactive, easy-to-use, menu-driven program which allows the user to investigate the pharmacokinetic relationships between the dose regimen of a drug administered to an individual, and the blood plasma concentration. A number of parameters may be selected: The individual may be "normal", suffering from severe liver damage or suffering severe kidney failure; A range of drugs are available: ampicillin, digoxin, propranolol, phenytoin, diazepam, lignocaine, quinidine, gentamicin and paracetamol; Different routes of administration: single i.v. dose, single oral dose, repeated i.v. dose, repeated oral dose, continuous i.v. infusion, single subcutaneous dose, single i.m. dose; Different dosage regimen: size of the drug dose, duration of the investigation, dose interval, and size of any loading dose administered. Once the program parameters have been selected, the program will calculate the drug plasma concentrations and present, on-screen, a variety of graphical (plasma concentration of drug (y-axis) against time (x-axis) using either linear x-y axes or log y linear x-axes) or numerical outputs. The display also shows recommended upper and lower plasma concentration levels for the chosen drug.

Comments & References: ISBN 1-874758-18-2. Suitable for Undergraduates studying medicine, dentistry, pharmacology, pharmacy and other biomedical science students. The program is supported by printed student-centred exercises. Also available on a floppy disc. System requirements: IBM PCs running Windows 3.1, 95, 98, 2000 or NT. This program complements the Drug Disposition Tutorials program (record number 1781) and it is recommended that they are used together as part of a structured teaching program. Suitable as an independent or classroom teaching tool.   Another description of this product is available from EURCA's (European Resource Centre for Alternatives in Higher Education) alternatives database (http://www.eurca.org/list_res.asp?CatID=All).

Computer type: IBM

Price: Departmental/multiuser licence: £250.00

Version: 2000